Miami, Florida Feb 5, 2026 (Issuewire.com) - In a recent report by ClickOnDetroit, Henry Ford Health psychiatrist Dr. Mansi Chawa raised a critical warning about the purity of saffron supplements available to consumers.
“Saffron is really expensive, and that’s actually a problem because over the years, there’s a lot of additives that have been added to it, a lot of fillers and other compounds,” Dr. Chawa told ClickOnDetroit. “If it’s adulterated with other substances, and if somebody is already taking medications, that could interact very dangerously with medications.”
This warning highlights a well-documented issue in the supplement industry. Saffron is the world’s most expensive spice by weight, making it one of the most frequently adulterated botanical ingredients on the market. Research has identified cases where commercial saffron products contain dyes, lower-grade plant material, or synthetic compounds substituted for genuine saffron stigmas.
Evolance Wellness Inc. (Evolance) selected Affron® — a patented saffron extract developed by Pharmactive Biotech Products S.L.U. — for its CADENCE™ Calm + Rest formula specifically because of this industry-wide purity concern.† Unlike generic saffron extracts, Affron® is the only saffron ingredient verified through DNA-certification technology, confirming species identity and ruling out adulteration in every batch, besides the complete and exhaustive set in-house of advanced analytical tests to detect even the minor adulteration.
“When a board-certified psychiatrist goes on mainstream media and specifically warns consumers about fillers in saffron supplements, it reinforces why ingredient verification matters,” said Andrei G., Head of Product Development at Evolance. “Our customers shouldn’t have to wonder whether what’s on the label matches what’s in the capsule. With Affron®, backed by DNA certification and 12 published clinical studies, they don’t have to.”
Affron® is supported by 12 published clinical studies and is the only saffron extract standardized to ≥3.5% Lepticrosalides® by HPLC. The extract has shown benefits for supporting mood balance, promoting sleep quality, and supporting the body’s natural response to occasional stress in clinical research settings.† Pharmactive Biotech Products, S.L.U. was an active contributor of the expert American Botanical Council’s Monograph “Saffron and Saffron Extracts - Botanical Adulterants Prevention Bulletin • March 2022”.
CADENCE™ Calm + Rest is officially available at the Evolance Store at www.evolance.com.
About Evolance Wellness Inc.
Evolance Wellness Inc. is a performance-wellness company producing clean-label, daily supplements designed to support energy, clarity, and recovery.† Guided by Trust Stack™ transparency initiative, Evolance develops products built on clinically studied ingredients and third-party testing. By partnering with industry leaders, Evolance continues to set new standards in quality and effectiveness.
About Affron®
Affron® is a patented, award-winning saffron extract developed by Pharmactive Biotech Products, S.L.U. It is the only saffron extract verified through DNA-certification technology and is standardized to ≥3.5% Lepticrosalides® by HPLC. Affron® is supported by 12 published clinical studies across mood, sleep, and stress support.
For more information, visit: https://pharmactive.eu/.
† These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Affron® is a registered trademark of Pharmactive Biotech Products, S.L.U. Lepticrosalides® is a registered trademark of Pharmactive Biotech Products, S.L.U.
Media Contact
Evolance Wellness Inc pr@evolance.com http://evolance.com
