New York City, New York Sep 15, 2021 (Issuewire.com) - Since the discovery of gamma delta T cells (γδ T cells), this rare and unique component of the immune system has been recognized for its potential in cancer immunotherapy. Creative Biolabs is a biotechnology company that has developed an advanced platform to help clients advance their T cell immunotherapy research by providing high-quality γδ T cell and a series of tailored γδ T cell-based drug development and discovery services.
Immunotherapies based on T cells are becoming a huge trend in the treatment of cancer, especially CAR-T cells. These genetically modified T cells have shown remarkable remission rates in patients that did not respond to standard treatments. Among the solutions emerging, a rare type of T cell called gamma delta T cells (γδ T cells) has attracted a great deal of attention because of their important role in fighting cancer. Besides, a published study revealed that the amount of γδ T cells that infiltrate a tumor was the best predictor of a favorable outcome for the patient.
Given the ability and benefits of γδ T cell, Creative Biolabs has focused on exploring γδ T cell technology to speed up the discovery and development of novel cancer immunotherapies. The services provided by Creative Biolabs include γδ T cell isolation, activation and expansion, characterization, production, cytotoxicity test, and migration assay, aiming to help explore more possible targeted drugs and help scientists develop solutions for cancer.
※ γδ T Cell Activation and Expansion
Immunotherapy with γδ T cells requires their activation and expansion as they comprise only a small percentage of circulating T cells. Appropriate optimization of human T cell activation and expansion protocols can improve the efficiency of genetic modification and overall cell yield. Some of the most commonly studied γδ T cells include Vγ9Vδ2 T cells and non-Vγ9Vδ2 T cells, as they can be activated and expanded in vitro and in vivo, thus make it possible to developing γδ T cell-based immunotherapy.
γδ T cells represent an evolutionarily primitive T cell subset characterized by distinct T cell receptors (TCRs) and innate and adaptive immune functions. The phenotypical and functional characterization of γδ T cells can help researchers understand intrinsic factors involved in cellular proliferation, function, and overall processes, and further advance the development of immunotherapy.
※ γδ T Cell Cytotoxicity Analysis
Cytotoxicity is the main biological effect of γδ T cells and the main way for them to exert anti-tumor effects. “Due to the important function of γδ T cell in several diseases, it is necessary to develop suitable pre-clinical assays for γδ T cell activity and cytotoxicity,” said a scientist at Creative Biolabs.
About Creative Biolabs
Equipped with deep knowledge and experience in γδ T cell design and production, Creative Biolabs can offer high-quality custom γδ T cell solutions for valued clients. Driven by science and a passion for quality, Creative Biolabs is committed to providing comprehensive, low-cost T cells support to meet the needs of customers.
Media Contact
Creative Biolabs marketing@creative-biolabs.com https://gammadelta-t-therapy.creative-biolabs.com/
